Infection, Causation and Indigenous Flora

Volume 3 • Issue 1 • 1000e104 J Aller Ther ISSN:2155-6121 JAT an open access journal Each unique microenvironment of the human body is colonized by indigenous flora generally believed to be present within a complex biofilm. The symbiosis that describes the relationship between endogenous flora and the host is not a static situation but a dynamic milieu capable of continuous change. As the microenvironment changes, the relative number and distribution of individual organisms change [1]. Everything from cigarette smoke [2] to the development of an oral cancer [3] have been shown to alter the composition of the indigenous flora on head and neck mucosa. Most relationships between organisms or between the host and the organism in the head and neck are either not known, poorly understood or both. At the heart of the problem is that we do not know the organisms present, much less the complex interrelationships between the microbes and their interactions with host defenses that lead to infection.